| pubmed-article:3994630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3994630 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:3994630 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:3994630 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:3994630 | pubmed:dateCreated | 1985-6-19 | lld:pubmed |
| pubmed-article:3994630 | pubmed:abstractText | We describe in vitro measurements of heteroduplex base mispaired intermediates involving 5-bromouracil and 2-aminopurine in A X T----G X C and G X C----A X T transition mutation pathways. For the case of 2-aminopurine, 2-aminopurine X cytosine mispairs are formed at a much higher frequency than adenine X cytosine mispairs in either transition pathway. For the case of 5-bromouracil, at least a 40-fold increase in 5-bromouracil X guanine mispairs are observed over thymine X guanine mispairs but only in the G X C----A X T pathway. In the A X T----G X C pathway, mispairs involving 5-bromouracil are formed 2.5-fold more frequently to those involving thymine suggesting perhaps that 5-bromouracil may exhibit substantially different base-pairing behavior depending on whether it is present as a template base or as a deoxyribonucleosides triphosphate substrate. The effect of the base analogs on dNTP pool size perturbations is discussed. A measurement of dNTP pools in 2-aminopurine mutagenized bacteriophage T4-infected cells is presented. An approximate eight-fold expansion in common dNTP pools is observed in a ts L141 antimutator genetic background compared to wild type T4 43+ and ts L56 mutator backgrounds. The effects of distorted dNTP pools on mutagenesis will be considered. | lld:pubmed |
| pubmed-article:3994630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3994630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3994630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3994630 | pubmed:issn | 0090-5542 | lld:pubmed |
| pubmed-article:3994630 | pubmed:author | pubmed-author:GoodmanM FMF | lld:pubmed |
| pubmed-article:3994630 | pubmed:author | pubmed-author:HopkinsR LRL | lld:pubmed |
| pubmed-article:3994630 | pubmed:author | pubmed-author:MhaskarD NDN | lld:pubmed |
| pubmed-article:3994630 | pubmed:author | pubmed-author:LaskenRR | lld:pubmed |
| pubmed-article:3994630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3994630 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:3994630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3994630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3994630 | pubmed:pagination | 409-23 | lld:pubmed |
| pubmed-article:3994630 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:meshHeading | pubmed-meshheading:3994630-... | lld:pubmed |
| pubmed-article:3994630 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3994630 | pubmed:articleTitle | The biochemical basis of 5-bromouracil- and 2-aminopurine-induced mutagenesis. | lld:pubmed |
| pubmed-article:3994630 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3994630 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3994630 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3994630 | lld:pubmed |
