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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-6-13
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Estrogen,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female--side...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Progestin,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/DERMATITIS,
http://linkedlifedata.com/resource/pubmed/keyword/Dermatological Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/ETHINYL ESTRADIOL,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/NORETHYNODREL,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Photodermatitis,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0365-6233
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
318
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-9
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pubmed:dateRevised |
2004-11-17
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pubmed:otherAbstract |
PIP: The photosensitized decomposition of the main steroids used in oral contraceptives was studied. Under the circumstances applied, ethinyl estradiol and norethynodrel decomposed rapidly (t 1/2 = 11.0 + or - 0.2 minutes for ethinyl estradiol and 5.7 + or - 0.4 minutes for norethynodrel). The decomposition product of ethinyl estradiol has been identified as 17 alpha-ethynyl-10 beta-hydroperoxy-17 beta-hydroxyestra-1,4-dien-3-one. The decomposition products of ethinyl estradiol and norethnodrel were previously found in experiments in which the irreversible binding of these steroids to protein was studied. Photosensitized decomposition of the steroids may be the cause of photoallergic side effects of "the pill."
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pubmed:meshHeading |
pubmed-meshheading:3994495-Contraceptives, Oral,
pubmed-meshheading:3994495-Contraceptives, Oral, Hormonal,
pubmed-meshheading:3994495-Drug Hypersensitivity,
pubmed-meshheading:3994495-Female,
pubmed-meshheading:3994495-Half-Life,
pubmed-meshheading:3994495-Humans,
pubmed-meshheading:3994495-Photochemistry,
pubmed-meshheading:3994495-Photosensitivity Disorders
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pubmed:year |
1985
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pubmed:articleTitle |
Photosensitized decomposition of contraceptive steroids: a possible explanation for the observed (photo)allergy of the oral contraceptive pill.
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pubmed:publicationType |
Journal Article
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