| pubmed-article:3990691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C0040669 | lld:lifeskim |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C1705794 | lld:lifeskim |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C0919425 | lld:lifeskim |
| pubmed-article:3990691 | lifeskim:mentions | umls-concept:C2267219 | lld:lifeskim |
| pubmed-article:3990691 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3990691 | pubmed:dateCreated | 1985-6-13 | lld:pubmed |
| pubmed-article:3990691 | pubmed:abstractText | An aryl hydrocarbon hydroxylase (AHH)-deficient gene A- mutant of the mouse line Hepa-1 was treated with calcium phosphate precipitates of DNA from Hepa-1, the rat line H4IIEC3, or an A- -human hybrid in which the A- mutation is complemented by the corresponding human gene. AHH+ transfectants were isolated by selection with benzo[ghi]perylene plus near UV. In addition, a gene A- mutant which also carries a mutation for hypoxanthine phosphoribosyltransferase deficiency was treated with the above genomic DNAs together with pSV2-gpt DNA, and cotransfectants were isolated after treatment with both benzo[ghi]pereylene and HAT. All transfectants and cotransfectants were inducible for AHH by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Both transfectants and cotransfectants were unstable during culture, rapidly losing AHH activity. Rat DNA-derived transfectants were probed in Southern blots with a cDNA probe to mouse cytochrome P1-450 that cross-hybridizes to the corresponding rat gene. All rat DNA-derived transfectants contained the rat P1-450 gene. In half of the transfectants, the rat gene was amplified four- to sevenfold. In one transfectant, the rat gene was truncated at the 3' end. The proportion of rat DNA in different transfectants, as determined by hybridization to a rat repetitive sequence, ranged from less than 1% to 5%. AHH activity and the rat P1-450 gene segregated together in subclones of one of the transfectants. These results demonstrate that the A gene is either the structural gene for cytochrome P1-450, or another very closely linked gene. Previous results (O. Hankinson et al., J. Biol. Chem. 260:1790-1795, 1985) favor the former alternative. | lld:pubmed |
| pubmed-article:3990691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3990691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3990691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3990691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3990691 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3990691 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3990691 | pubmed:author | pubmed-author:HankinsonOO | lld:pubmed |
| pubmed-article:3990691 | pubmed:author | pubmed-author:MontisanoD... | lld:pubmed |
| pubmed-article:3990691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3990691 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3990691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3990691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3990691 | pubmed:pagination | 698-704 | lld:pubmed |
| pubmed-article:3990691 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:meshHeading | pubmed-meshheading:3990691-... | lld:pubmed |
| pubmed-article:3990691 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3990691 | pubmed:articleTitle | Transfection by genomic DNA of cytochrome P1-450 enzymatic activity and inducibility. | lld:pubmed |
| pubmed-article:3990691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3990691 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3990691 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3990691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3990691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3990691 | lld:pubmed |
