rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
1985-6-20
|
pubmed:abstractText |
Spleen cells from C.B- 17 scid mice with severe combined immunodeficiency disease exhibit natural killer cell (NK) activity against YAC lymphoma targets in a standard 4-hr 51Cr release assay. The cytolytic activity is demonstrable only at high effector to target ratios but can be augmented at least sevenfold by the interferon inducer poly I:C. The pattern of target lysis is specific, because splenocytes from poly I:C-primed C.B-17 scid mice lyse NK-sensitive YAC cells and not the insensitive P815 mastocytoma. The presence of several NK-associated antigens on C.B-17 scid splenocytes was tested by pretreating cells with the appropriate antiserum plus complement before testing for NK activity. The results indicate that a proportion of NK effectors in C.B-17 scid mice bear surface NK 2.1 and Asialo GM1 but are negative for Thy-1.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0022-1767
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
134
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3798-801
|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3989296-Animals,
pubmed-meshheading:3989296-Antibodies, Monoclonal,
pubmed-meshheading:3989296-Cytotoxicity, Immunologic,
pubmed-meshheading:3989296-G(M1) Ganglioside,
pubmed-meshheading:3989296-Glycosphingolipids,
pubmed-meshheading:3989296-Immunologic Deficiency Syndromes,
pubmed-meshheading:3989296-Isoantibodies,
pubmed-meshheading:3989296-Killer Cells, Natural,
pubmed-meshheading:3989296-Lymphoma,
pubmed-meshheading:3989296-Mice,
pubmed-meshheading:3989296-Mice, Mutant Strains,
pubmed-meshheading:3989296-Phenotype,
pubmed-meshheading:3989296-Spleen
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pubmed:year |
1985
|
pubmed:articleTitle |
Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid).
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|