Linked Life Data

3988390

Source:http://linkedlifedata.com/resource/pubmed/id/3988390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-6-6
pubmed:abstractText
In eight healthy young volunteers, 15 g of activated charcoal administered orally 30 min after 50 mg of doxepin, reduced the achieved peak concentration of the drug in serum by 70% and total availability by 49%. Charcoal, 3 hours after the drug, did not significantly reduce absorption. When charcoal was administered 30 min after doxepin, the apparent elimination half-lives of doxepin and its main metabolite, desmethyldoxepin, were prolonged by 350 and 140%, respectively, suggesting gradual disaggregation of the charcoal-drug complex. Repeated doses of charcoal between 3 and 24 hours after doxepin increased significantly the apparent clearance of desmethyldoxepin. Repeated doses of charcoal may be beneficial in the treatment of overdosage with doxepin by preventing disaggregation of the drug from an initial dose of charcoal with subsequent absorption and reabsorption of parent drug and metabolites secreted into the gastrointestinal tract.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-42
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of single and repeated doses of activated charcoal on the pharmacokinetics of doxepin.
pubmed:publicationType
Journal Article