Linked Life Data

3985276

Source:http://linkedlifedata.com/resource/pubmed/id/3985276

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-5-1
pubmed:abstractText
Experiments were conducted to determine the effect of anti-schistosomal vaccine exposure on the level of pre-existing resistance in mice with a bisexual Schistosoma mansoni infection. C57BL/6 mice with light S. mansoni infections of 8 weeks duration were injected with 10 Krad-irradiated, cryopreserved and thawed schistosomules. Four weeks later the mice were exposed to normal cercariae, and adult worms collected by perfusion 6 weeks post-challenge. In 4 experiments, the baseline levels of resistance in infected mice ranged from 19% to 50% reduction in challenge worm burden (mean of 36%). Although vaccine administration slightly raised the overall level of resistance in infected mice (mean of 49%), in only 1 experiment was the increase over that in infected mice statistically significant. The levels of resistance attributed to the patent infection and vaccine exposure were not additive. Vaccine exposure had no effect on recovery of the adult worms of the primary infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of a cryopreserved live vaccine on resistance in mice with a pre-existing Schistosoma mansoni infection.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't