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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-5-10
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pubmed:abstractText |
Calcific degeneration is the main cause of porcine bioprosthetic valve failure. This dystrophic phenomenon has been studied by transmission electron microscopy in 26 explants; six normally processed unimplanted xenografts and a pig aortic valve from the slaughterhouse served as controls. Loss of endothelial lining and proteoglycans were a regular finding in all the commercially processed valves. In order to detect initial calcifications, we investigated in particular areas apparently devoid of mineralization at x-ray. Three main ultramicroscopic features were found: 1) intracytoplasmic and interstitial calcospherulae in 22 explants, 2) calcified collagen fibrils in 15, and 3) platelike calcium deposits upon amorphous material in 3. X-ray diffraction and energy-dispersive microanalysis identified Ca2+ deposits as crystals of hydroxyapatite. From these findings there is evidence that debris and membrane fragments of the pig cusp cells represent one of the initial nuclei of calcification.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-1068450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-1248649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-409267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-4195919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-5291227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-5775794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6603825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6604449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6605687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6702684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6731274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6810028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6831947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-6865456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-7062771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-7127695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-7132412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3985118-7192049
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3985118-Animals,
pubmed-meshheading:3985118-Aortic Valve,
pubmed-meshheading:3985118-Bioprosthesis,
pubmed-meshheading:3985118-Calcinosis,
pubmed-meshheading:3985118-Collagen,
pubmed-meshheading:3985118-Heart Valve Diseases,
pubmed-meshheading:3985118-Heart Valve Prosthesis,
pubmed-meshheading:3985118-Humans,
pubmed-meshheading:3985118-Microscopy, Electron,
pubmed-meshheading:3985118-Rats,
pubmed-meshheading:3985118-Swine
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pubmed:year |
1985
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pubmed:articleTitle |
Ultrastructural substrates of dystrophic calcification in porcine bioprosthetic valve failure.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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