Linked Life Data

3973

Source:http://linkedlifedata.com/resource/pubmed/id/3973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1976-5-10
pubmed:abstractText
The effects of luminal addition of salicylate and taurocholate on ion transport by fundic mucosa were examined in vitro using isotopic and pH stat techniques. Salicylate, 3 mM, did not alter, but 20 mM caused a 40% decrease in, the acid secretory rate. Taurocholate, 20 mM, caused a transient, apparent cessation of acid secretion followed by stimulation. Salicylate, 3 or 20 mM, increased Na+ but not Cl- permeability at luminal pH 7. At luminal pH 4, however, salicylate increased Cl- in addition to Na+ and H+ permeability. Taurocholate, 10 or 20 mM, increased both cation and anion permeability at pH 7 and 4. Addition of salicylate or taurocholate results in stimulation of net Na+ transport. While salicylate and taurocholate increase cation permeability at pH 7, they have differing effects on acid secretion and anion permeability. The data suggest that salicylate and taurocholate alter cation permeability by different mechanisms and are consistent with the concept that enhanced diffusion of H+ into the tissue causes a nonspecific alteration in the permeability pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
230
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Effects of salicylate and bile salt on ion transport by isolated gastric mucosa of the rabbit.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.