Linked Life Data

3967857

Source:http://linkedlifedata.com/resource/pubmed/id/3967857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-3-18
pubmed:abstractText
New techniques have been developed employing microlight guides and miniature O2 electrodes which permit metabolic events to be studied noninvasively in periportal and pericentral zones of the liver lobule. These events include O2 uptake, fat and carbohydrate metabolism, monooxygenation and glucuronidation. The lobular distribution of maximal enzyme activities measured by immunohistochemical or microchemical techniques does not always correlate with metabolic flux rates as measured in periportal and pericentral regions with the new noninvasive methods. The region of the liver lobule exhibiting highest metabolic flux rates can be shifted to another region of the lobule by changing the direction of flow from anterograde to retrograde. These data are consistent with the hypothesis that many metabolic pathways (e.g., oxygen, carbohydrate and fat metabolism which are under dynamic short-term regulation) operate below maximal velocity in intact hepatocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-9139
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-51
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:articleTitle
Sublobular compartmentation of pharmacologic events (SCOPE): metabolic fluxes in periportal and pericentral regions of the liver lobule.
pubmed:publicationType
Journal Article