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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1985-3-12
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pubmed:abstractText |
The level of plasma copper (Cu-Pl) and zinc (Zn-Pl) and the level of erythrocyte iron (Fe-RBC), copper (Cu-RBC), and zinc (Zn-RBC) were determined in the blood of 70 normal donors and 138 patients with various solid tumors by diagnostic x-ray spectrometry (DXS), a technique based on x-ray fluorescence spectrometry analysis. There were no significant changes in the mean values of Zn-Pl, Fe-RBC, and Cu-RBC in the patients when compared with those of normal donors. The mean level of Cu-Pl in the normal donors was 1.34 +/- 0.37 micrograms/ml; it was significantly increased in the patients, ranging between 1.47 +/- 0.34 micrograms/ml for patients without evidence of active cancer (NED) and 1.91 +/- 0.76 micrograms/ml for patients with hepatic metastases. The most significant change observed was an increase in the Zn-RBC found in the patients with clinical evidence of metastatic spread. Whereas the Zn-RBC level in the normal donors was 9.85 +/- 1.47 micrograms/g wet weight, and not significantly elevated in the NED patients, it was elevated to values of 11.37 +/- 1.55 micrograms/g (P less than 0.004) for patients with soft tissue and hepatic metastases and was 12.34 +/- 1.65 micrograms/g (P less than 0.001) for patients with bone metastases. The data suggest a clear correlation between Zn-RBC and metastatic spread in nonlymphomatous human cancer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
779-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3967173-Bone Neoplasms,
pubmed-meshheading:3967173-Copper,
pubmed-meshheading:3967173-Erythrocytes,
pubmed-meshheading:3967173-Female,
pubmed-meshheading:3967173-Humans,
pubmed-meshheading:3967173-Iron,
pubmed-meshheading:3967173-Liver Neoplasms,
pubmed-meshheading:3967173-Male,
pubmed-meshheading:3967173-Neoplasm Metastasis,
pubmed-meshheading:3967173-Neoplasms,
pubmed-meshheading:3967173-Plasma,
pubmed-meshheading:3967173-Soft Tissue Neoplasms,
pubmed-meshheading:3967173-Spectrometry, X-Ray Emission,
pubmed-meshheading:3967173-Zinc
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pubmed:year |
1985
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pubmed:articleTitle |
Correlation of erythrocyte and plasma levels of zinc, copper, and iron with evidence of metastatic spread in cancer patients.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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