Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Pt 2
|
| pubmed:dateCreated |
1986-5-8
|
| pubmed:abstractText |
An absence of gene(s) on the Rb locus of chromosome 13 or a disturbance of its normal expression in the retinoblasts of the embryonic retina predisposes an individual to the development of retinoblastoma. Chromosome aberrations involving 13q14 comprised about 14% of newly arising germinal mutations. Chromosome analysis of retinoblastoma tumor cells revealed that the generation of an extra copy of the long arm of chromosome 1 or the short arm of chromosome 6 is an early event in many of the tumors and plays a significant role in engendering tumorigenicity of retinoblasts already having one mutation at the Rb locus.
|
| pubmed:language |
jpn
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0385-0684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
645-51
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3963835-Chromosome Aberrations,
pubmed-meshheading:3963835-Chromosomes, Human, 13-15,
pubmed-meshheading:3963835-Eye Neoplasms,
pubmed-meshheading:3963835-Female,
pubmed-meshheading:3963835-Humans,
pubmed-meshheading:3963835-Male,
pubmed-meshheading:3963835-Mutation,
pubmed-meshheading:3963835-Retinoblastoma
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
[Hereditary tumors and chromosome aberrations with special reference to retinoblastoma].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|