Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1980-6-25
pubmed:abstractText
1. Tienilic acid and hydrochlorothiazide were evaluated in a double-blind trial in order to investigate their antihypertensive and metabolic effects. 2. After 5 weeks, the decreases in blood pressure and the changes in plasma or serum electrolytes, urea, creatinine, glucose, cholesterol and triglycerides, and in creatinine clearance, did not differ in the two groups of patients. 3. In patients taking tienilic acid a significant decrease in serum uric acid and an increase in urate clearance was observed, whereas in patients receiving hydrochlorothiazide a slight increase in serum uric acid, with no modification of urate clearance, occurred. 4. The diuretic and antihypertensive actions of tienilic acid and hydrochlorothiazide are very similar. The uricosuric/hypouricaemic effect of tienilic acid could assume clinical relevance in long-term therapy of hypertensive patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
57 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367s-269s
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:396083-Adolescent, pubmed-meshheading:396083-Adult, pubmed-meshheading:396083-Aged, pubmed-meshheading:396083-Blood Glucose, pubmed-meshheading:396083-Blood Pressure, pubmed-meshheading:396083-Cholesterol, pubmed-meshheading:396083-Clinical Trials as Topic, pubmed-meshheading:396083-Creatinine, pubmed-meshheading:396083-Double-Blind Method, pubmed-meshheading:396083-Electrolytes, pubmed-meshheading:396083-Female, pubmed-meshheading:396083-Glycolates, pubmed-meshheading:396083-Heart Rate, pubmed-meshheading:396083-Humans, pubmed-meshheading:396083-Hydrochlorothiazide, pubmed-meshheading:396083-Hypertension, pubmed-meshheading:396083-Male, pubmed-meshheading:396083-Middle Aged, pubmed-meshheading:396083-Posture, pubmed-meshheading:396083-Ticrynafen, pubmed-meshheading:396083-Triglycerides, pubmed-meshheading:396083-Uric Acid
pubmed:year
1979
pubmed:articleTitle
An evaluation of tienilic acid, a new diuretic uricosuric agent, in the therapy of arterial hypertension.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Controlled Clinical Trial