pubmed-article:3954750 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3954750 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
pubmed-article:3954750 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
pubmed-article:3954750 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
pubmed-article:3954750 | lifeskim:mentions | umls-concept:C0005196 | lld:lifeskim |
pubmed-article:3954750 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:3954750 | pubmed:dateCreated | 1986-4-16 | lld:pubmed |
pubmed-article:3954750 | pubmed:abstractText | The beta-bungarotoxin-induced depolarization of the synaptosomal plasma membrane monitored by the efflux of 86Rb+ is potentiated by raising the albumin in the incubation, is Ca2+-dependent and is due neither to inhibition of the (Na+ + K+)-dependent ATPase nor to activation of the voltage-dependent Na+ channel. Occupancy of the beta-bungarotoxin-binding site by dendrotoxin inhibits partially the action of beta-bungarotoxin. The efflux of 86Rb+ is parallelled by a release of lactate dehydrogenase from the synaptosome, and the two processes are maximal with 2 nM-toxin. Digitonin induces a release of 86Rb+ and lactate dehydrogenase closely similar to that seen with beta-bungarotoxin. It is concluded that the toxicity of beta-bungarotoxin for mammalian nerve terminals can be largely accounted for by specific site-directed phospholipase A2-induced permeabilization of the plasma membrane. | lld:pubmed |
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pubmed-article:3954750 | pubmed:language | eng | lld:pubmed |
pubmed-article:3954750 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3954750 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3954750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:3954750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3954750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3954750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:3954750 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3954750 | pubmed:month | Jan | lld:pubmed |
pubmed-article:3954750 | pubmed:issn | 0264-6021 | lld:pubmed |
pubmed-article:3954750 | pubmed:author | pubmed-author:NichollsD GDG | lld:pubmed |
pubmed-article:3954750 | pubmed:author | pubmed-author:DollyJ OJO | lld:pubmed |
pubmed-article:3954750 | pubmed:author | pubmed-author:RugoloMM | lld:pubmed |
pubmed-article:3954750 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3954750 | pubmed:day | 15 | lld:pubmed |
pubmed-article:3954750 | pubmed:volume | 233 | lld:pubmed |
pubmed-article:3954750 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3954750 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3954750 | pubmed:pagination | 519-23 | lld:pubmed |
pubmed-article:3954750 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:3954750 | pubmed:meshHeading | pubmed-meshheading:3954750-... | lld:pubmed |
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pubmed-article:3954750 | pubmed:year | 1986 | lld:pubmed |
pubmed-article:3954750 | pubmed:articleTitle | The mechanism of action of beta-bungarotoxin at the presynaptic plasma membrane. | lld:pubmed |
pubmed-article:3954750 | pubmed:publicationType | Journal Article | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3954750 | lld:pubmed |