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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-4-16
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pubmed:abstractText |
The beta-bungarotoxin-induced depolarization of the synaptosomal plasma membrane monitored by the efflux of 86Rb+ is potentiated by raising the albumin in the incubation, is Ca2+-dependent and is due neither to inhibition of the (Na+ + K+)-dependent ATPase nor to activation of the voltage-dependent Na+ channel. Occupancy of the beta-bungarotoxin-binding site by dendrotoxin inhibits partially the action of beta-bungarotoxin. The efflux of 86Rb+ is parallelled by a release of lactate dehydrogenase from the synaptosome, and the two processes are maximal with 2 nM-toxin. Digitonin induces a release of 86Rb+ and lactate dehydrogenase closely similar to that seen with beta-bungarotoxin. It is concluded that the toxicity of beta-bungarotoxin for mammalian nerve terminals can be largely accounted for by specific site-directed phospholipase A2-induced permeabilization of the plasma membrane.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-1151385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-198683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-303565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-348200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-38654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-4052016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-4214556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-4407099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-6102747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-6123559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-6247959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-6275072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-670979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-7107594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-7171991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-7173209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-7353009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-7370008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-82447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3954750-831804
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
233
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3954750-Animals,
pubmed-meshheading:3954750-Bungarotoxins,
pubmed-meshheading:3954750-Cations, Divalent,
pubmed-meshheading:3954750-Digitonin,
pubmed-meshheading:3954750-Elapid Venoms,
pubmed-meshheading:3954750-Guinea Pigs,
pubmed-meshheading:3954750-L-Lactate Dehydrogenase,
pubmed-meshheading:3954750-Membrane Potentials,
pubmed-meshheading:3954750-Ouabain,
pubmed-meshheading:3954750-Serum Albumin,
pubmed-meshheading:3954750-Synaptic Membranes
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pubmed:year |
1986
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pubmed:articleTitle |
The mechanism of action of beta-bungarotoxin at the presynaptic plasma membrane.
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pubmed:publicationType |
Journal Article
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