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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1979-11-28
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pubmed:abstractText |
Cocaine (20 mg/kg, i.p.) stimulated spontaneous motor activity (SMA) and induced stereotypy (ST) in rats. Haloperidol at 0.015 mg/kg, i.p. dose reduced or blocked cocaine-induced ST, but did not affect, drug-induced hyperactivity. At 0.03 mg/kg, i.p. dose of haloperidol, both behavioral effects were blocked. Cocaine decreased the norepinephrine (NE) and serotonin (5-HT) contents of diencephalon-midbrain (DM) and pons-medulla (PM) and increased dopamine (DA) contents in the DM and caudate nucleus (CN) at 20 min after its administration. Haloperidol (0.03 or 0.015 mg/kg) at 30 min postdrug produced opposite effects on the levels of NE, DA and 5-HT in the respective brain areas compared to cocaine. Given in combination, haloperidol reversed the effects of cocaine on the levels of NE, DA and 5-HT. Thus the cocaine-induced behavioral changes and their modification by haloperidol can be correlated to the neurochemical changes produced by these drugs alone or their combination.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0301-4533
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
238
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-80
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:39530-Animals,
pubmed-meshheading:39530-Behavior, Animal,
pubmed-meshheading:39530-Brain Chemistry,
pubmed-meshheading:39530-Cocaine,
pubmed-meshheading:39530-Drug Interactions,
pubmed-meshheading:39530-Haloperidol,
pubmed-meshheading:39530-Humans,
pubmed-meshheading:39530-Male,
pubmed-meshheading:39530-Motor Activity,
pubmed-meshheading:39530-Neurotransmitter Agents,
pubmed-meshheading:39530-Rats,
pubmed-meshheading:39530-Stereotyped Behavior,
pubmed-meshheading:39530-Time Factors
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pubmed:year |
1979
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pubmed:articleTitle |
Modification of behavioral and neurochemical effects of cocaine by haloperidol.
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pubmed:publicationType |
Journal Article
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