| pubmed-article:3949984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3949984 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3949984 | lifeskim:mentions | umls-concept:C0008328 | lld:lifeskim |
| pubmed-article:3949984 | lifeskim:mentions | umls-concept:C0017127 | lld:lifeskim |
| pubmed-article:3949984 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3949984 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3949984 | pubmed:dateCreated | 1986-4-24 | lld:pubmed |
| pubmed-article:3949984 | pubmed:abstractText | In the present study we used a bioassay system for measuring plasma cholecystokinin (CCK) to evaluate whether CCK has a physiologic role in regulating gastric emptying in humans. Plasma CCK levels and gastric emptying after ingestion of a mixed liquid meal were determined in five normal male volunteers. Fasting CCK levels averaged 0.8 +/- 0.1 pM and increased to 6.5 +/- 1.0 pM within 10 min of drinking the mixed meal. CCK levels remained elevated for up to 90 min. Gastric emptying after a meal was slow; at the end of the 90 min 68% of the original volume remained in the stomach. The rate of gastric emptying of water was then measured in the same individuals with a simultaneous infusion of either saline, or one of two doses of CCK (12 pmol/kg per h and 24 pmol/kg per h). With the saline infusion, plasma CCK levels did not increase above basal and gastric contents emptied rapidly. At the end of 90 min only 7% of the original volume remained in the stomach. The lower dose of CCK resulted in a plasma level of 3.4 pM which both reproduced the average postprandial plasma level and caused a significant delay in gastric emptying. The higher dose of CCK achieved plasma levels of 8 pM and resulted in a delay in gastric emptying that was similar to that seen with the mixed meal. Since exogenous CCK at concentrations which occur postprandially delays gastric emptying, we conclude that CCK is a physiologic regulator of gastric emptying. | lld:pubmed |
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| pubmed-article:3949984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3949984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3949984 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3949984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3949984 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3949984 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:3949984 | pubmed:author | pubmed-author:WilliamsJ AJA | lld:pubmed |
| pubmed-article:3949984 | pubmed:author | pubmed-author:LiddleR ARA | lld:pubmed |
| pubmed-article:3949984 | pubmed:author | pubmed-author:MoritaE TET | lld:pubmed |
| pubmed-article:3949984 | pubmed:author | pubmed-author:ConradC KCK | lld:pubmed |
| pubmed-article:3949984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3949984 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:3949984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3949984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3949984 | pubmed:pagination | 992-6 | lld:pubmed |
| pubmed-article:3949984 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3949984 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3949984 | pubmed:articleTitle | Regulation of gastric emptying in humans by cholecystokinin. | lld:pubmed |
| pubmed-article:3949984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3949984 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3949984 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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