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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-4-24
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pubmed:abstractText |
In the present study we used a bioassay system for measuring plasma cholecystokinin (CCK) to evaluate whether CCK has a physiologic role in regulating gastric emptying in humans. Plasma CCK levels and gastric emptying after ingestion of a mixed liquid meal were determined in five normal male volunteers. Fasting CCK levels averaged 0.8 +/- 0.1 pM and increased to 6.5 +/- 1.0 pM within 10 min of drinking the mixed meal. CCK levels remained elevated for up to 90 min. Gastric emptying after a meal was slow; at the end of the 90 min 68% of the original volume remained in the stomach. The rate of gastric emptying of water was then measured in the same individuals with a simultaneous infusion of either saline, or one of two doses of CCK (12 pmol/kg per h and 24 pmol/kg per h). With the saline infusion, plasma CCK levels did not increase above basal and gastric contents emptied rapidly. At the end of 90 min only 7% of the original volume remained in the stomach. The lower dose of CCK resulted in a plasma level of 3.4 pM which both reproduced the average postprandial plasma level and caused a significant delay in gastric emptying. The higher dose of CCK achieved plasma levels of 8 pM and resulted in a delay in gastric emptying that was similar to that seen with the mixed meal. Since exogenous CCK at concentrations which occur postprandially delays gastric emptying, we conclude that CCK is a physiologic regulator of gastric emptying.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-1126597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-1127608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-1175886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-2580857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-404865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-4745816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-5423893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-5639357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6204904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6259918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6269946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6338170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6338172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6401407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-645853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6839908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6883724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-6897537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-7081475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-7141133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-7153912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-7194753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-722578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-727254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-7413793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3949984-964568
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
992-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1986
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pubmed:articleTitle |
Regulation of gastric emptying in humans by cholecystokinin.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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