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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-4-17
|
| pubmed:abstractText |
Amiodarone, used in the treatment of cardiac arrhythmia, may lead to severe discolouration of sun-exposed skin. The lysosomal storage of a lipid-like material has been shown to be the morphological substrate for this cutaneous hyperpigmentation. Examination of peripheral white blood cells of amiodarone-treated patients disclosed identical lysosomal structures indicating that amiodarone treatment leads to a more generalized lysosomal storage of lipids and of amiodarone and its metabolites.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0007-0963
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
189-96
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3947537-Amiodarone,
pubmed-meshheading:3947537-Benzofurans,
pubmed-meshheading:3947537-Humans,
pubmed-meshheading:3947537-Leukocytes,
pubmed-meshheading:3947537-Lysosomes,
pubmed-meshheading:3947537-Microscopy, Electron,
pubmed-meshheading:3947537-Photosensitivity Disorders,
pubmed-meshheading:3947537-Pigmentation Disorders,
pubmed-meshheading:3947537-Skin
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Morphological changes in peripheral blood cells and skin in amiodarone-treated patients.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|