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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1986-3-5
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pubmed:abstractText |
We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding a source of complement. Despite apparent lack of disease specificity, such factors might damage oligodendrocytes if they gained access to these cells through a damaged blood-brain barrier in MS or other disorders.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-3878
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3945400-Adult,
pubmed-meshheading:3945400-Animals,
pubmed-meshheading:3945400-Complement System Proteins,
pubmed-meshheading:3945400-Cytotoxicity, Immunologic,
pubmed-meshheading:3945400-Guinea Pigs,
pubmed-meshheading:3945400-Hot Temperature,
pubmed-meshheading:3945400-Humans,
pubmed-meshheading:3945400-Middle Aged,
pubmed-meshheading:3945400-Multiple Sclerosis,
pubmed-meshheading:3945400-Neuroglia,
pubmed-meshheading:3945400-Oligodendroglia,
pubmed-meshheading:3945400-Rabbits,
pubmed-meshheading:3945400-Rats
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pubmed:year |
1986
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pubmed:articleTitle |
Serum-mediated oligodendrocyte cytotoxicity in multiple sclerosis patients and controls.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|