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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1986-3-7
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pubmed:abstractText |
Intranasal administration of norethisterone at a daily dose of 9 micrograms between Days 5 and 14 of the menstrual cycles blocked ovulation in 10 out of 17 adult female monkeys. Serum concentrations of hormones indicated that ovulation was blocked due to a suppression of the mid-cycle, oestradiol-induced LH surge. Ovarian follicular activity in the treated menstrual cycles was not affected by norethisterone but there was a marked delay in the onset of the mid-cycle oestradiol surge in most of the treated animals. The duration of the menstrual cycle length after the oestradiol peak was significantly reduced in all the treated monkeys, indicative of a shortened luteal phase.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0022-4251
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3944792-Administration, Intranasal,
pubmed-meshheading:3944792-Animals,
pubmed-meshheading:3944792-Estradiol,
pubmed-meshheading:3944792-Female,
pubmed-meshheading:3944792-Luteinizing Hormone,
pubmed-meshheading:3944792-Macaca,
pubmed-meshheading:3944792-Menstrual Cycle,
pubmed-meshheading:3944792-Norethindrone,
pubmed-meshheading:3944792-Ovarian Follicle,
pubmed-meshheading:3944792-Ovulation,
pubmed-meshheading:3944792-Progesterone
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pubmed:year |
1986
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pubmed:articleTitle |
Reproductive endocrine effects of intranasal administration of norethisterone to adult female rhesus monkeys (Macaca mulatta).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|