Linked Life Data

3944385

Source:http://linkedlifedata.com/resource/pubmed/id/3944385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-3-24
pubmed:abstractText
The morphology and airflow behavior in the nose are considered briefly in relationship to the various ways that are often used to evaluate the spray or aerosol discharged from inhalation delivery systems. A glass-model nose of a design based on published anatomic measurements is described. Its use is described for examining the major sites of drug deposition from nasal delivery systems. That no significant differences are detected between the regional deposition from a metered aerosol and a metered-pump product confirm what might be expected from the nasal anatomy. Most of the drug in each case is deposited in the anterior region of the nose by inertial impaction, and there is little nasal penetration of the drug. Inhaled airflow at 10 L/min through one side of the nose has little effect on regional deposition. The anteriorly deposited drug can be spread backward by mucociliary flow and general surface flow, factors that are essentially independent of the presentation used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
348-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
A comparison of the regional deposition in a model nose of a drug discharged from metered aerosol and metered-pump nasal delivery systems.
pubmed:publicationType
Journal Article, Comparative Study