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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1986-2-14
|
| pubmed:abstractText |
A study was performed on the antiviral effects of human interferon-alpha (MOR-22) produced by a human lymphoblastoid cell line (BALL-1). Of 4 DNA and 9 RNA viruses used in this study, all were inhibited by the IFN-alpha and the IC90s obtained were 10(1)-10(4) IU/ml. Results showed that IFN-alpha had a very wide antiviral spectrum. The IFN-alpha was able to induce 2',5'-oligo A synthetase activity in RSa, HeLa S3 and M08 cell lines but not in a HEC-IC cell line lacking receptors for IFN-alpha. This strongly suggests that one of the antiviral mechanisms might function through the induction of 2',5'-oligo A synthetase activity through the IFN-alpha receptor.
|
| pubmed:language |
jpn
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0385-0684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
122-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3942393-2',5'-Oligoadenylate Synthetase,
pubmed-meshheading:3942393-Antiviral Agents,
pubmed-meshheading:3942393-DNA Viruses,
pubmed-meshheading:3942393-Enzyme Induction,
pubmed-meshheading:3942393-Humans,
pubmed-meshheading:3942393-Interferon Type I,
pubmed-meshheading:3942393-RNA Viruses
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
[Basic study on human lymphoblastoid interferon-alpha (MOR-22): Part I. Antiviral effect].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|