Linked Life Data

3940823

Source:http://linkedlifedata.com/resource/pubmed/id/3940823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-2-6
pubmed:abstractText
Gastric inhibitory polypeptide (GIP), given to dogs in graded doses (range 0.25-2 micrograms/kg/hr) against a constant background stimulation with pentagastrin (4 micrograms/kg/hr), failed to affect the acid secretion at all doses used except the largest one (2 micrograms/kg/hr) which significantly reduced the acid secretion only from the vagally denervated portion of the stomach (Heidenhain pouch, HP) while raising plasma GIP two to three times above the levels reached with duodenal fat. GIP infused in a constant dose (1 microgram/kg/hr) significantly reduced the HP responses to lower (0.5-2 micrograms/kg/hr) but not to higher (4-16 micrograms/kg/hr) doses of pentagastrin, the kinetics of this inhibition being of competitive type. GIP was ineffective against a constant near maximal stimulation with pentagastrin (4 micrograms/kg/hr), histamine (40 micrograms/kg/hr), or liver extract meal, whereas fat (10 g), given intraduodenally or intravenously, was a powerful inhibitor of acid responses to these stimulants both from the innervated and denervated stomach. Plasma GIP reached similar levels with exogenous GIP and duodenal fat but remained unchanged with intravenous infusion of fat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0163-2116
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Comparison of gastric inhibitory polypeptide and intraduodenal or intravenous fat on gastric acid secretion from vagally innervated and denervated canine stomach.
pubmed:publicationType
Journal Article, Comparative Study