Linked Life Data

3937535

Source:http://linkedlifedata.com/resource/pubmed/id/3937535

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1986-3-5
pubmed:abstractText
Lipoprotein patterns and cholesteryl ester transfer activity (CETA) were examined in 2 patients with familial hyperalphalipoproteinaemia (FHALP). The proband was a healthy 58-year-old Japanese male who had an HDL cholesterol of 7.83 mmol/l (301 mg/dl). His sister's HDL cholesterol was 4.52 mmol/l (174 mg/dl), which suggested that both were homozygous carriers of FHALP. In both subjects HDL showed a high cholesterol/apo A-I ratio and appeared to be a larger-sized particle than normal HDL on agarose gel chromatography. Two of the proband's children showed higher HDL cholesterol levels (1.74 mmol/l, 2.16 mmol/l) than normal, but another 2 children showed normal levels (1.48 mmol/l, 1.40 mmol/l). However, the ratios of HDL cholesterol to total cholesterol and to apo A-I in all children were higher than normal. These data suggest, but do not prove, that all his children were heterozygotes. Apo B levels in all of the family members studied were lower than normal (47-80 mg/dl). Deceased members of the same family had not died from cardiovascular disease. Cholesteryl-ester transfer activity was studied in both patients. When serum or lipoprotein deficient serum (d greater than 1.21) and [3H]cholesteryl ester labelled HDL3 were incubated in the presence of an LCAT inhibitor, there was no evidence of cholesteryl ester transfer from HDL to VLDL and/or LDL, unlike normal subjects. The deficiency of CETA in these patients with FHALP presumably accounted for the increase in particle size and cholesterol enrichment of HDL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-86
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:3937535-Adult, pubmed-meshheading:3937535-Aged, pubmed-meshheading:3937535-Apolipoprotein A-I, pubmed-meshheading:3937535-Apolipoproteins A, pubmed-meshheading:3937535-Apolipoproteins B, pubmed-meshheading:3937535-Carrier Proteins, pubmed-meshheading:3937535-Child, pubmed-meshheading:3937535-Cholesterol, HDL, pubmed-meshheading:3937535-Cholesterol Ester Transfer Proteins, pubmed-meshheading:3937535-Female, pubmed-meshheading:3937535-Glycoproteins, pubmed-meshheading:3937535-Heterozygote, pubmed-meshheading:3937535-Homozygote, pubmed-meshheading:3937535-Humans, pubmed-meshheading:3937535-Hyperlipoproteinemias, pubmed-meshheading:3937535-Male, pubmed-meshheading:3937535-Middle Aged, pubmed-meshheading:3937535-Pedigree, pubmed-meshheading:3937535-Phosphatidylcholine-Sterol O-Acyltransferase
pubmed:year
1985
pubmed:articleTitle
Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinaemia.
pubmed:publicationType
Journal Article, Case Reports