Linked Life Data

3936464

Source:http://linkedlifedata.com/resource/pubmed/id/3936464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-1-30
pubmed:abstractText
The cannulated prescapular lymph node of the foetal lamb was challenged with killed Brucella abortus. Usually, both efferent prescapular ducts were cannulated and one node left as a control. Nodes were given primary or secondary challenges with doses of 10(9) - 2 X 10(10) brucella organisms and the lymph-borne response of the nodes followed. The foetal lymph node produced a vigorous cellular response to the injected brucella, restricted to the challenged side. The total cell output and, more strikingly, large cell output increased to reach a peak value 4-5 days after challenge. This cellular response was seemingly dose-dependent. The output of antibody after a primary challenge was delayed considerably and could not be detected in the lymph until well after the cellular response had subsided. The concentrations of antibody produced were quite low and almost all mercaptoethanol-sensitive. With secondary challenges the output of antibody occurred much more quickly, in phase with the cellular response, and appreciable amounts of mercaptoethanol-resistant antibody were produced. Under exceptional circumstances, high titre, highly specific anti-brucella antibody has been produced in foetal lymph. The foetal lymph node provides a powerful tool for further studies of the ontogeny of the immune response, and might help elucidate the failure of newborn animals to respond to some important bacterial antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0004-945X
pubmed:author
pubmed:issnType
Print
pubmed:volume
63 ( Pt 4)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The lymph-borne response of foetal lamb lymph nodes to challenge with Brucella abortus in utero.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't