Linked Life Data

3935699

Source:http://linkedlifedata.com/resource/pubmed/id/3935699

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1986-2-17
pubmed:abstractText
An in situ ovine liver perfusion technique was developed and used to study glucagon effects on utilization of simultaneously infused propionic acid and amino acids. Physiological amounts of propionic acid and amino acids (hydrolyzed casein) were infused into livers along with carbon-14 propionic acid or carbon-14 threonine with and without glucagon. Glucagon (5 mg) caused a 75% increase of glucose synthesis and a 19% increase of labeled carbon dioxide production from carbon-14 propionic acid. There also was a decrease of perfusate urea nitrogen when glucagon was present. Glucagon caused a 76% decrease of carbon-14 threonine utilization by ovine livers, and labeled carbon dioxide production from carbon-14 threonine was only 38% of control when glucagon was infused. From these results, glucagon caused an increase of use of propionic acid and a decrease of use of threonine for energetic pathways in sheep liver. Therefore, glucagon directly or indirectly may mediate amino acid sparing by ruminant liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-0302
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2886-94
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Glucagon influence on gluconeogenesis and oxidation of propionic acid and threonine by perfused ovine liver.
pubmed:publicationType
Journal Article