| pubmed-article:3935435 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3935435 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:3935435 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:3935435 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:3935435 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:3935435 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3935435 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3935435 | pubmed:dateCreated | 1986-1-30 | lld:pubmed |
| pubmed-article:3935435 | pubmed:abstractText | The extent and kinetics of induction have been determined for eight mRNAs induced by alpha- and gamma-interferons in HeLa cells. The mRNAs which code for a 2-5A synthetase, metallothionein II, HLA class I antigen and five unknown proteins were induced 2 - greater than 100-fold by alpha-interferons. In the continued presence of alpha-interferon some mRNAs were maintained at the induced levels until at least 40 h, whereas others were induced only transiently. When the effects of alpha- and gamma-interferons were compared, the induced levels and kinetics were very similar for one mRNA (1-8) but were significantly different for the others. One mRNA (6-16) was induced more than 100-fold by alpha-interferon but not significantly by gamma-interferon. Parallel analysis of the level of c-myc mRNA showed it to decrease twofold in response to alpha-interferon, but to increase more than threefold in response to gamma-interferon, despite a more profound inhibition of cell growth by the latter. There must, therefore, be differences in how the levels of different mRNAs are sustained by alpha-interferons and how alpha- and gamma-interferons regulate the levels of the same mRNAs. | lld:pubmed |
| pubmed-article:3935435 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3935435 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3935435 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3935435 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3935435 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3935435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3935435 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3935435 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:3935435 | pubmed:author | pubmed-author:StarkG RGR | lld:pubmed |
| pubmed-article:3935435 | pubmed:author | pubmed-author:KellyJ MJM | lld:pubmed |
| pubmed-article:3935435 | pubmed:author | pubmed-author:GilbertC SCS | lld:pubmed |
| pubmed-article:3935435 | pubmed:author | pubmed-author:KerrI MIM | lld:pubmed |
| pubmed-article:3935435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3935435 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:3935435 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:3935435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3935435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3935435 | pubmed:pagination | 367-71 | lld:pubmed |
| pubmed-article:3935435 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3935435 | pubmed:meshHeading | pubmed-meshheading:3935435-... | lld:pubmed |
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| pubmed-article:3935435 | pubmed:meshHeading | pubmed-meshheading:3935435-... | lld:pubmed |
| pubmed-article:3935435 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3935435 | pubmed:articleTitle | Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons. | lld:pubmed |
| pubmed-article:3935435 | pubmed:publicationType | Journal Article | lld:pubmed |
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