Linked Life Data

3935435

Source:http://linkedlifedata.com/resource/pubmed/id/3935435

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-1-30
pubmed:abstractText
The extent and kinetics of induction have been determined for eight mRNAs induced by alpha- and gamma-interferons in HeLa cells. The mRNAs which code for a 2-5A synthetase, metallothionein II, HLA class I antigen and five unknown proteins were induced 2 - greater than 100-fold by alpha-interferons. In the continued presence of alpha-interferon some mRNAs were maintained at the induced levels until at least 40 h, whereas others were induced only transiently. When the effects of alpha- and gamma-interferons were compared, the induced levels and kinetics were very similar for one mRNA (1-8) but were significantly different for the others. One mRNA (6-16) was induced more than 100-fold by alpha-interferon but not significantly by gamma-interferon. Parallel analysis of the level of c-myc mRNA showed it to decrease twofold in response to alpha-interferon, but to increase more than threefold in response to gamma-interferon, despite a more profound inhibition of cell growth by the latter. There must, therefore, be differences in how the levels of different mRNAs are sustained by alpha-interferons and how alpha- and gamma-interferons regulate the levels of the same mRNAs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2956
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367-71
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons.
pubmed:publicationType
Journal Article