Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-2-12
pubmed:abstractText
Authors emphasize the pathogenetic importance of fungous dimorphism and its consequence in the usefulness of antimycotic drugs. For the study of drugs' activity on C. albicans, two models for the evaluation on yeast or mycelial form were developed. The first model is of candida growth on an animal cell culture, where a good mycelial form develops during the first 24 hours: authors demonstrated a synergism of the amphotericin B-rifampin combination, which is less evident in the traditional in vitro tests, and some activity of tolcyclate. The second model is an intracutaneous injection in the guinea pig of C. albicans, which quickly develops in the mycelial form, infiltrating the skin layers. Some interesting differences were recorded, comparing amphotericin B and ketoconazole. Moreover the authors used a therapy test in mice, based mainly on examination of the kidney.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0392-906X
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
406-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
In vivo tests for antimycotic drugs.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro