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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1985-12-26
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pubmed:abstractText |
Rat liver microsomal enzyme(s) that catalyze mutagenic activation of a carcinogenic aminoazo dye, 3-methoxy-4-aminoazobenzene (3-MeO-AAB), was studied by virtue of the Salmonella typhimurium TA98 assay using o-aminoazotoluene (OAT) as the control. Male Wistar rats were pretreated with phenobarbital (PB), 3-methylcholanthrene (MC) or polychlorinated biphenyl (PCB), and the liver microsomal activities for mutagenic activation of 3-MeO-AAB and OAT were examined. In agreement with the reported results on several carcinogenic aromatic amines, MC pretreatment resulted in greater activation of microsomal activity in the OAT mutagenesis (about a 4-fold increase as compared to the untreated control) than did PB (1.5-fold increase). By contrast, the mutagenic activation of 3-MeO-AAB is found to be more efficiently catalyzed by those enzyme(s) that are induced by PB pretreatment (4-fold increase) than by those that are induced by MC (1.8-fold increase). The induced enzymes that principally mediate the mutagenic activation of these azo dyes are indicated to be cytochrome P-450s, because the mutagenic activation was strongly inhibited by addition of cytochrome P-450 inhibitors such as 2-diethylaminoethyl-2,2-diphenylvalerate (SKF 525A) and 7,8-benzoflavone. These data suggest that 3-MeO-AAB is a unique carcinogenic aromatic amine as a substrate for mutagenic activation via catalysis of those cytochrome P-450s that are induced by PB pretreatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-methoxy-4-aminoazobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Azo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Methylcholanthrene,
http://linkedlifedata.com/resource/pubmed/chemical/Phenobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Polychlorinated Biphenyls,
http://linkedlifedata.com/resource/pubmed/chemical/p-Aminoazobenzene
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pubmed:status |
MEDLINE
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pubmed:issn |
0027-5107
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3934534-Animals,
pubmed-meshheading:3934534-Azo Compounds,
pubmed-meshheading:3934534-Biotransformation,
pubmed-meshheading:3934534-Carcinogens,
pubmed-meshheading:3934534-Cytochrome P-450 Enzyme System,
pubmed-meshheading:3934534-Kinetics,
pubmed-meshheading:3934534-Male,
pubmed-meshheading:3934534-Methylcholanthrene,
pubmed-meshheading:3934534-Microsomes, Liver,
pubmed-meshheading:3934534-Mutagenicity Tests,
pubmed-meshheading:3934534-Mutation,
pubmed-meshheading:3934534-Phenobarbital,
pubmed-meshheading:3934534-Polychlorinated Biphenyls,
pubmed-meshheading:3934534-Rats,
pubmed-meshheading:3934534-Rats, Inbred Strains,
pubmed-meshheading:3934534-Salmonella typhimurium,
pubmed-meshheading:3934534-p-Aminoazobenzene
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pubmed:articleTitle |
3-Methoxy-4-aminoazobenzene, a unique carcinogenic aromatic amine as a substrate for cytochrome-P-450-mediated mutagenesis.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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