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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1986-1-23
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pubmed:abstractText |
Twelve cases of T gamma LPD (lymphoproliferative disorders of Fc gamma receptor-bearing T cells) involving an expansion of large granular lymphocyte/natural killer (LGL/NK) cells were investigated for the expression of LGL/NK-associated markers and for T beta gene rearrangement. All the cases selected were classified as T gamma LPD on the basis of morphology, function, and phenotype of the circulating cells. 10 to 12 cases displayed clonal rearrangements of the T beta locus and expression of the T3 antigen, whereas the 2 remaining cases displayed the germline configuration of the T beta gene and no expression of the T3 antigen. T8, Mol, B73.1, and N901 antigens were variably expressed among both T beta+T3+ and T beta-T3- T gamma LPD cases. We suggest that individual T gamma LPD cases represent the clonal expansion of cells frozen at different stages of differentiation/activation within an individual hematopoietic LGL/NK lineage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-2409597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-2416719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6191218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6201674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6238640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6326893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6333925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6574190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6790607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6823293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6975300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-6988511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-7172502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3934321-7430655
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2156-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3934321-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3934321-Antigens, Surface,
pubmed-meshheading:3934321-Cytotoxicity, Immunologic,
pubmed-meshheading:3934321-Humans,
pubmed-meshheading:3934321-Killer Cells, Natural,
pubmed-meshheading:3934321-Leukemia,
pubmed-meshheading:3934321-Lymphocytosis,
pubmed-meshheading:3934321-Lymphoproliferative Disorders,
pubmed-meshheading:3934321-Nucleic Acid Hybridization,
pubmed-meshheading:3934321-Phenotype,
pubmed-meshheading:3934321-Receptors, Antigen, T-Cell,
pubmed-meshheading:3934321-T-Lymphocytes
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pubmed:year |
1985
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pubmed:articleTitle |
T cell receptor beta chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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