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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-1-23
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pubmed:abstractText |
The human T cell subset(s) responsible for the production of soluble factors that can modulate B cell growth and B cell differentiation was investigated in the present study. For this purpose, highly purified OKT4+ and OKT8+ lymphocytes were stimulated with phytohaemagglutinin and phorbol myristate acetate. Subsequently, culture supernatants were analysed for B cell growth factor (BCGF) activity and B cell differentiation factor (BCDF) activity in the following systems: 1) maintenance of a proliferative state of Staphylococcus aureus of strain Cowan I (SAC)-stimulated B cells and 2) induction of plaque-forming cell responses of SAC-stimulated B cells. Mitogenic stimulation led to production of equivalent amounts of either BCGF activity or BCDF activity from both of the OKT4+ and OKT8+ subsets. These findings may provide a basis for further studies of the molecular mechanisms as well as cellular interactions involved in human B cell activation, proliferation and differentiation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-1080773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-315070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-3156746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-3917275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-49107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6088664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6198432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6204796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6209044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6211485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6213706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6219882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6223093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6227636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6234113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6335391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6335652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6401797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6413637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6434689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6446683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6457863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6458039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6459343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6808028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6980419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6980918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-6984061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3933868-789096
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3933868-Adult,
pubmed-meshheading:3933868-Antibodies, Monoclonal,
pubmed-meshheading:3933868-Antigens, Bacterial,
pubmed-meshheading:3933868-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:3933868-Antigens, Surface,
pubmed-meshheading:3933868-B-Lymphocytes,
pubmed-meshheading:3933868-Growth Substances,
pubmed-meshheading:3933868-Humans,
pubmed-meshheading:3933868-Interleukin-4,
pubmed-meshheading:3933868-Lymphocyte Activation,
pubmed-meshheading:3933868-Lymphocyte Cooperation,
pubmed-meshheading:3933868-Phytohemagglutinins,
pubmed-meshheading:3933868-Staphylococcus aureus,
pubmed-meshheading:3933868-T-Lymphocytes,
pubmed-meshheading:3933868-Tetradecanoylphorbol Acetate
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pubmed:year |
1985
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pubmed:articleTitle |
OKT4+ and OKT8+ T lymphocytes produce soluble factors that can modulate growth and differentiation of human B cells.
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pubmed:publicationType |
Journal Article
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