Linked Life Data

3932954

Source:http://linkedlifedata.com/resource/pubmed/id/3932954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-11-26
pubmed:abstractText
Sustained convulsive seizures were induced with bicuculline in newborn rabbits and marmoset monkeys. In both species, seizures were predominantly tonic, with generalized polyspikes on the EEG. Brain glucose concentration fell dramatically during seizures in both species, and in many normoglycemic animals reached levels usually associated with severe hypoglycemia, suggesting that glucose transport from blood to brain could not keep pace with glucose utilization. Glucose loads given to rabbits induced hyperglycemia and during seizures maintained brain glucose well above concentrations needed to saturate hexokinase so that glycolytic rates were probably never limited by substrate availability. Blood and brain lactate concentrations rose during seizures but never reached levels considered cytotoxic. These data suggest that epileptic seizures can deplete brain glucose in normoglycemic neonates of several species, including subhuman primates.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
992-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Neonatal seizures in monkeys and rabbits: brain glucose depletion in the face of normoglycemia, prevention by glucose loads.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't