Linked Life Data

3932448

Source:http://linkedlifedata.com/resource/pubmed/id/3932448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-12-13
pubmed:abstractText
Idiopathic isolated gonadotropin deficiency (IGD) is associated with a spectrum of clinical findings as well as variable gonadotropin responses to GnRH. In this study we investigated whether patterns of gonadotropin and testosterone responses to pulsatile GnRH therapy (25 ng/kg, iv, every 2 h for 4 days) were related to the magnitude of the GnRH secretory defect in patients with IGD. Eight men with IGD were studied. Patients with partial IGD (p-IGD) and those who had no evidence of GnRH secretion (n-IGD) were differentiated by the presence or absence of spontaneous LH secretory pulses during 24 h of every 20-min blood sampling. In response to the first GnRH injection, no LH rise occurred in the n-IGD patients, while LH increases in the p-IGD patients were similar to those in normal men. Continuation of GnRH therapy in patients with n-IGD resulted in predominant FSH secretion and absent or minimal augmentation of LH and T secretion. In contrast, predominant LH secretion occurred in the p-IGD patients and resulted in a significant increase in serum testosterone. A bolus dose of GnRH 2 days after the termination of GnRH therapy caused significant augmentation of gonadotropin responses in the n-IGD, while in the p-IGD group, both LH and FSH responses were unchanged compared to those after the first GnRH pulse. These results indicate that IGD is characterized by variable degrees of endogenous GnRH deficiency. Moreover, the hormone responses to GnRH in IGD patients depend on the magnitude of the underlying GnRH secretory defect.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1118-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Idiopathic hypogonadotropic hypogonadism in men: dependence of the hormone responses to gonadotropin-releasing hormone (GnRH) on the magnitude of the endogenous GnRH secretory defect.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.