Linked Life Data

3931933

Source:http://linkedlifedata.com/resource/pubmed/id/3931933

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-12-9
pubmed:abstractText
Although considerable work is being carried out with pyridoxalated glutaraldehyde-stabilized stroma-free hemoglobin solution (SFHS-pp) as a possible blood substitute, it is not known whether the SFHS-pp has any adverse effect on some aspects of reticuloendothelial (RE) function. To determine this, 131I-gelatinized trioleate (GT) was injected 30 min or 3 days after the injection of 45 or 100 mg/100 gm BW SFHS-pp (low and high dose, respectively). The results indicate that low as well as high dose SFHS-pp significantly decreased splenic uptake and transiently increased pulmonary uptake of GT. Hepatic retention of GT, however, increased 3 days following SFHS-pp administration, indicating that there was a stimulation of this aspect of liver RE function at that time. The intravascular clearance rates of GT at 3 days were also markedly faster, but no dose effect relationship was seen. This suggests that there was an overall stimulation of RE function 3 days following SFHS-pp administration. These results provide support for the safety of polymerized stroma-free hemoglobin solution for use as an oxygen-carrying volume support.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0092-6213
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-72
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of pyridoxalated stabilized stroma-free hemoglobin solution on the clearance of intravascular lipid by the reticuloendothelial system.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.