Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-12-6
|
| pubmed:abstractText |
The frequency and clinical significance of acute leukemia displaying both lymphoid and myeloid characteristics was determined in 123 consecutive children using a panel of lineage-associated markers. The leukemic blasts from 18 of 95 children (19%) with the diagnosis of acute lymphoblastic leukemia (ALL) by standard diagnostic criteria expressed myeloid-associated cell surface antigens. Despite immunological evidence of lymphoid differentiation (17 CALLA + and one T cell-associated antigen +) and findings of immunoglobulin gene rearrangement, blasts from these patients reacted with one to five monoclonal antibodies identifying myeloid-associated cell surface antigens (My-1, MCS.2, Mo1, SJ-D1, or 5F1). Dual staining with microsphere-conjugated antibodies and analysis by flow cytometry confirmed that some blasts were simultaneously expressing lymphoid- and myeloid-associated antigens. Conversely, blasts from seven of 28 patients (25%) with acute nonlymphocytic leukemia (ANLL), diagnosed by otherwise standard morphological and cytochemical criteria, expressed lymphoid-associated surface antigens. Dual staining of individual blasts demonstrated simultaneous expression of myeloperoxidase (MPO) (including Auer rods) in association with either T-11, CALLA, or terminal deoxynucleotidyl transferase. Blasts from one patient with ANLL demonstrated T cell receptor gene rearrangement, while blasts from another patient demonstrated characteristics associated with T (T-11), B (CALLA and heavy-chain immunoglobulin gene rearrangement), and myeloid (MPO) lineage. There were no consistent cytogenetic abnormalities, and no patient demonstrated independent leukemic clones. Each patient with typical ALL, except for myeloid-associated antigens, achieved complete remission with conventional induction therapy for ALL. By contrast, three of the seven children with ANLL whose blasts expressed the T-11 surface antigen failed ANLL induction therapy. These three patients subsequently achieved remission with ALL therapy.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1115-23
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3931724-Acute Disease,
pubmed-meshheading:3931724-Adolescent,
pubmed-meshheading:3931724-Age Factors,
pubmed-meshheading:3931724-Antibodies, Monoclonal,
pubmed-meshheading:3931724-Antigens, Neoplasm,
pubmed-meshheading:3931724-Antigens, Surface,
pubmed-meshheading:3931724-B-Lymphocytes,
pubmed-meshheading:3931724-Child,
pubmed-meshheading:3931724-Child, Preschool,
pubmed-meshheading:3931724-Female,
pubmed-meshheading:3931724-Genes, MHC Class II,
pubmed-meshheading:3931724-Humans,
pubmed-meshheading:3931724-Infant,
pubmed-meshheading:3931724-Leukemia,
pubmed-meshheading:3931724-Leukemia, Lymphoid,
pubmed-meshheading:3931724-Leukemia, Myeloid, Acute,
pubmed-meshheading:3931724-Leukocyte Count,
pubmed-meshheading:3931724-Male,
pubmed-meshheading:3931724-Microspheres,
pubmed-meshheading:3931724-Neoplastic Stem Cells,
pubmed-meshheading:3931724-Prognosis
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Acute mixed lineage leukemia: clinicopathologic correlations and prognostic significance.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|