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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1985-10-29
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pubmed:abstractText |
The efficacy of an emulsion of perfluorochemicals (Fluosol-DA) to sensitize RIF-1 tumors of C3H mice to radiation was studied. An i.v. injection of 12 ml/kg of Fluosol-DA (20%) to tumor-bearing animals and keeping the animals in an atmosphere of a mixture of O2 (95%) and CO2 (5%) (carbogen) for 1 hr before and during irradiation of s.c. tumors in the thigh significantly enhanced the tumoricidal effect of radiation as measured with growth delay of the treated tumors. A lesser but significant enhancement of radiation damage in the tumors was also observed when the animals were kept in carbogen for 1 hr without injection of Fluosol-DA. It was concluded that Fluosol-DA increased the delivery of oxygen to hypoxic areas in the tumors and enhanced the response of hypoxic cells to radiation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0360-3016
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1833-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3930442-Animals,
pubmed-meshheading:3930442-Carbon Dioxide,
pubmed-meshheading:3930442-Drug Combinations,
pubmed-meshheading:3930442-Fluorocarbons,
pubmed-meshheading:3930442-Mice,
pubmed-meshheading:3930442-Mice, Inbred C3H,
pubmed-meshheading:3930442-Neoplasms, Experimental,
pubmed-meshheading:3930442-Oxygen,
pubmed-meshheading:3930442-Radiation-Sensitizing Agents
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pubmed:year |
1985
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pubmed:articleTitle |
Increased radiosensitivity of tumors by perfluorochemicals and carbogen.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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