Linked Life Data

3930084

Source:http://linkedlifedata.com/resource/pubmed/id/3930084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-11-20
pubmed:abstractText
We observed a significant reduction in one specific T-cell rosetting marker after treatment of bovine lymph node lymphocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA). There was a dose-dependent reduction in the formation of neuraminidase-treated sheep erythrocyte rosettes (En), but not aminoethylisothiouronium bromide-treated sheep rosettes (Ea) after as little as 10 min of incubation with TPA. A maximum of approximately 50% reduction was reached after 1 h. When several phorbol esters and mezerien were tested, we found that the reduction in En rosetting induced by the compounds correlated with their in vivo tumor-promoting activity. The reduction in En rosetting appears to be approximately 50% reversible for up to 6 h of treatment with TPA when the cells were incubated in TPA-free medium for an additional 24 h, but it was irreversible after at least 12 h of treatment. Addition of the tumor promoters directly to the rosetting assay had no detectable effect on the sheep erythrocytes or the percentage of Ea rosettes. This specific change in En rosetting marker may represent the maturation of a T-cell subpopulation to T-suppressor cells in the presence of tumor-promoting phorbol esters.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1435-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Changes in a T-cell subpopulation marker induced by tumor-promoting phorbol esters.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.