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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-11-7
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pubmed:abstractText |
Exposure of spleen cells from athymic nude mice to Pseudomonas aeruginosa exotoxin A induces these cells to respond to the thymus-dependent (TD) antigen sheep erythrocytes (SRBC). The response induced by toxin is dose dependent, antigen specific, and not due to polyclonal B-cell activation. Enhancement of the anti-SRBC response can be observed when toxin addition precedes antigen stimulation by 24-48 hr, which decreases when toxin administration follows antigen stimulation. A significant response is also observed when toxin and antigen are added simultaneously. A significant anti-SRBC response can be observed out to Day 10 postantigen and toxin stimulation after attaining a peak response at Day 5. Cultures exposed to toxin in the presence or absence of antigen exhibited a higher cell number and relative number of B cells as compared to control cultures. Exposure of T-cell depleted B cells from euthymic +/nu mice to toxin plus antigen does not result in an anti-SRBC response indicating that exotoxin A alone is not sufficient to induce B-cell responsiveness to T-dependent antigens and that other cells and/or factors are involved in the toxin-induced responsiveness of nude mice to T-dependent antigens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP Ribose Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Group Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Exotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Ficoll,
http://linkedlifedata.com/resource/pubmed/chemical/Haptens,
http://linkedlifedata.com/resource/pubmed/chemical/TNP-ficoll,
http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors,
http://linkedlifedata.com/resource/pubmed/chemical/toxA protein, Pseudomonas aeruginosa
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-75
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3930073-ADP Ribose Transferases,
pubmed-meshheading:3930073-Animals,
pubmed-meshheading:3930073-Antibody Formation,
pubmed-meshheading:3930073-B-Lymphocytes,
pubmed-meshheading:3930073-Bacterial Toxins,
pubmed-meshheading:3930073-Blood Group Antigens,
pubmed-meshheading:3930073-Dose-Response Relationship, Immunologic,
pubmed-meshheading:3930073-Exotoxins,
pubmed-meshheading:3930073-Ficoll,
pubmed-meshheading:3930073-Haptens,
pubmed-meshheading:3930073-Hemolytic Plaque Technique,
pubmed-meshheading:3930073-Kinetics,
pubmed-meshheading:3930073-Mice,
pubmed-meshheading:3930073-Mice, Nude,
pubmed-meshheading:3930073-Pseudomonas aeruginosa,
pubmed-meshheading:3930073-Sheep,
pubmed-meshheading:3930073-T-Lymphocytes,
pubmed-meshheading:3930073-Trinitrobenzenes,
pubmed-meshheading:3930073-Virulence Factors
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pubmed:year |
1985
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pubmed:articleTitle |
Induction of an immune response in athymic nude mice to thymus-dependent antigens by Pseudomonas aeruginosa exotoxin A.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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