Linked Life Data

3927322

Source:http://linkedlifedata.com/resource/pubmed/id/3927322

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-9-16
pubmed:abstractText
Investigations were undertaken with 5,7-dihydroxytryptamine and 6-hydroxydopamine treated rats to see whether activity changes induced by TRH, ethanol and the TRH-ethanol combination would be affected after reduced monoamine function. In keeping with earlier results, TRH increased activity, ethanol reduced activity and the TRH-ethanol combination produced activity counts greater than those for TRH alone. Neither the 5,7-dihydroxytryptamine-induced reduction of brain serotonin nor the 6-hydroxydopamine treatments which reduced brain catecholamines altered the hyperactivity induced by TRH or the TRH-ethanol combination. While reduction of brain serotonin did not affect the ethanol-induced changes in activity, preferential reduction of dopamine as well as reduction of both norepinephrine and dopamine significantly antagonized this measure of ethanol-induced depression. The reduction of dopamine alone produced the greatest effect on this action of ethanol. It can be concluded from the data that the increased locomotion induced by TRH and the TRH-ethanol combination does not depend upon endogenous monoamines, whereas the sedative effects of ethanol are apparently influenced by alterations in brain catecholamine function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1013-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effects of TRH, ethanol, and TRH-ethanol combination on activity in rats with altered monoamine content.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't