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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1985-8-28
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pubmed:abstractText |
We have examined the in vitro phosphorylation of cellular src protein (pp60c-src) molecules associated with the polyoma virus middle-sized tumor antigen in polyoma virus-transformed cells. These pp60c-src molecules possessed an enhanced tyrosyl kinase activity, migrated aberrantly on NaDodSO4/polyacrylamide gels, and contained a novel site of tyrosine phosphorylation within the amino-terminal region of the molecule. The pp60c-src molecules not associated with the middle-sized tumor antigen were phosphorylated exclusively on a tyrosine residue within the carboxyl-terminal domain of pp60c-src. A similar modified form of the middle-sized tumor antigen-associated pp60c-src protein was detected in lysates from polyoma virus-transformed cells labeled in vivo with [32P]orthophosphate in the presence of sodium orthovanadate, an inhibitor of phosphotyrosyl phosphatases.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-144127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-219258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-2981329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-2987799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-4288238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-4318787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-486156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6087323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6091900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6095053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6167574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6183663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6184609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6193631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6204986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6251974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6253141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6265803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6273838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6276761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6280176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6282832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6282833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6287461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6296132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6304524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6312092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6314123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6325177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6426802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6434530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6574475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-6574482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3927285-73183
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Polyomavirus Transforming,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral, Tumor,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein pp60(v-src),
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4568-72
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3927285-Animals,
pubmed-meshheading:3927285-Antibodies, Monoclonal,
pubmed-meshheading:3927285-Antigens, Polyomavirus Transforming,
pubmed-meshheading:3927285-Antigens, Viral, Tumor,
pubmed-meshheading:3927285-Cell Line,
pubmed-meshheading:3927285-Cells, Cultured,
pubmed-meshheading:3927285-Oncogene Protein pp60(v-src),
pubmed-meshheading:3927285-Peptide Fragments,
pubmed-meshheading:3927285-Phosphorylation,
pubmed-meshheading:3927285-Protein Kinases,
pubmed-meshheading:3927285-Rats,
pubmed-meshheading:3927285-Rats, Inbred F344,
pubmed-meshheading:3927285-Transfection,
pubmed-meshheading:3927285-Tyrosine,
pubmed-meshheading:3927285-Viral Proteins
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pubmed:year |
1985
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pubmed:articleTitle |
Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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