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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1985-9-19
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pubmed:abstractText |
The effects of DA agonists and antagonists with different dopamine (DA) D-1 and D-2 receptor selectivity have been studied in rats with bilateral 6-OHDA lesions. The D-1 agonist SK & F 38393, the D-2 agonist pergolide and the mixed agonist apomorphine all induced marked hyperactivity in lesioned rats in doses which were without stimulant effect in sham-operated animals. The hyperactivity induced by SK & F 38393 was blocked by the DA D-1 antagonist SCH 23390, but unaffected by the D-2 antagonists spiroperidol or clebopride. Pergolide-induced hyperactivity showed the reverse selectivity. The mixed D-1/D-2 antagonists, cis(Z)-flupentixol and cis(Z)-clopenthixol, however blocked the effect of both agonists. Apomorphine-induced hyperactivity was neither blocked by selective D-1 nor D-2 antagonists, but was dose-dependently inhibited by cis(Z)-flupentixol and cis(Z)-clopenthixol. Potent blockade was also obtained by combined treatment with SCH 23390 and spiroperidol, indicating the need of blocking both D-1 and D-2 receptors simultaneously. The results indicate that D-1 and D-2 receptor function can be independently manipulated in denervated rats and they confirm similar results obtained in rats with unilateral 6-OHDA lesions using circling behaviour.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p...,
http://linkedlifedata.com/resource/pubmed/chemical/Apomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Clopenthixol,
http://linkedlifedata.com/resource/pubmed/chemical/Ergolines,
http://linkedlifedata.com/resource/pubmed/chemical/Flupenthixol,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxydopamines,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Pergolide,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Spiperone,
http://linkedlifedata.com/resource/pubmed/chemical/clebopride
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
717-23
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3927097-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine,
pubmed-meshheading:3927097-Animals,
pubmed-meshheading:3927097-Apomorphine,
pubmed-meshheading:3927097-Benzamides,
pubmed-meshheading:3927097-Benzazepines,
pubmed-meshheading:3927097-Clopenthixol,
pubmed-meshheading:3927097-Dopamine,
pubmed-meshheading:3927097-Dose-Response Relationship, Drug,
pubmed-meshheading:3927097-Ergolines,
pubmed-meshheading:3927097-Flupenthixol,
pubmed-meshheading:3927097-Hydroxydopamines,
pubmed-meshheading:3927097-Hypothalamus,
pubmed-meshheading:3927097-Male,
pubmed-meshheading:3927097-Motor Activity,
pubmed-meshheading:3927097-Oxidopamine,
pubmed-meshheading:3927097-Pergolide,
pubmed-meshheading:3927097-Rats,
pubmed-meshheading:3927097-Rats, Inbred Strains,
pubmed-meshheading:3927097-Receptors, Dopamine,
pubmed-meshheading:3927097-Spiperone
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pubmed:year |
1985
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pubmed:articleTitle |
Hyperactivity induced by stimulation of separate dopamine D-1 and D-2 receptors in rats with bilateral 6-OHDA lesions.
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pubmed:publicationType |
Journal Article
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