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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1985-9-12
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pubmed:abstractText |
The enantiomers of cis-5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin and its methyl ether have been synthesized. The compounds were tested for central dopamine (DA) receptor activity, by using biochemical and behavioral tests in rats. The (1R,2S)-(-) enantiomers of 1 and 2 are characterized as centrally acting DA-receptor agonists while the corresponding (1S,2R)-(+) enantiomers are characterized as centrally acting DA-receptor antagonists. Compounds (+)-1 and (+)-2 differ from classical neuroleptics in being able to increase DA synthesis rate in a wide dose range without reducing locomotor activity, suggesting a pronounced selectivity for DA autoreceptors. Also the (-) enantiomers seem to act preferentially on DA autoreceptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1049-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3927002-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:3927002-Animals,
pubmed-meshheading:3927002-Brain,
pubmed-meshheading:3927002-Dihydroxyphenylalanine,
pubmed-meshheading:3927002-Male,
pubmed-meshheading:3927002-Motor Activity,
pubmed-meshheading:3927002-Naphthalenes,
pubmed-meshheading:3927002-Rats,
pubmed-meshheading:3927002-Rats, Inbred Strains,
pubmed-meshheading:3927002-Receptors, Dopamine,
pubmed-meshheading:3927002-Stereoisomerism,
pubmed-meshheading:3927002-Tetrahydronaphthalenes
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pubmed:year |
1985
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pubmed:articleTitle |
Novel dopamine receptor agonists and antagonists with preferential action on autoreceptors.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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