Linked Life Data

3926808

Source:http://linkedlifedata.com/resource/pubmed/id/3926808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-9-16
pubmed:abstractText
The mechanism of impaired calcium absorption in postmenopausal osteoporosis is controversial. If it is caused by calcitriol deficiency, it should be corrected by long term administration of physiological doses of this metabolite, whereas if it is caused by either a primary defect in calcium absorption or intestinal resistance to calcitriol action, it should not be. In 56 osteoporotic women, mean (+/- SE) fractional calcium absorption (0.52 +/- 0.02) was lower (P less than 0.001) than that in 20 age-matched normal women (0.61 +/- 0.02). Treatment with calcitriol (0.5-0.75 micrograms/day) increased calcium absorption after 6-12 months to 0.67 +/- 0.02 (P less than 0.001) and, in 29 patients, to 0.66 +/- 0.02 (P less than 0.001) after 24 months. After treatment, only 1 patient still had subnormal calcium absorption. In 26 patients treated with placebo for 6-12 months, there was no significant change in calcium absorption. For all studies, total calcium absorption (fractional absorption X estimated dietary intake) correlated directly with urinary calcium excretion (r = 0.61; P less than 0.001). Urinary hydroxyproline excretion, an index of bone resorption, was 31.0 +/- 1.5 mg/dl glomerular filtration rate (GFR) initially and decreased during treatment to 24.6 +/- 1.1 mg/dl GFR (P less than 0.001) after 6-12 months and to 27.9 +/- 1.3 mg/dl GFR (P less than 0.01) after 24 months. The finding that calcium absorption can be normalized by small doses of calcitriol supports the hypothesis that insufficient endogenous production of calcitriol is the major cause of decreased calcium absorption in postmenopausal osteoporosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
457-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of long term treatment with calcitriol on calcium absorption and mineral metabolism in postmenopausal osteoporosis.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Controlled Clinical Trial