Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-9-16
pubmed:abstractText
Staphylococcus aureus, the Pseudomonas aeruginosa temperature-sensitive (ts) mutant A/10/25, and the P. aeruginosa parental wild type were aerosolized to C5-deficient mice, and the total number of polymorphonuclear leukocytes (PMN) recovered by lung lavage was determined 4 h after aerosol exposure. S. aureus induced a slight but significant recruitment of PMN, as compared with the effect of a saline aerosol. Both wild-type P. aeruginosa and the ts mutant induced a significant PMN recruitment of a magnitude ca. 180 times higher than that produced by S. aureus. Gentamicin-killed ts P. aeruginosa induced a PMN recruitment of a magnitude similar to that produced by live ts P. aeruginosa. Thorough washing of the bacteria, however, removed ca. 90% of the chemotactic activity. Exposure of the animals to a ts P. aeruginosa culture supernatant aerosol induced significant PMN recruitment into the lower airways. The same culture supernatants were chemotactic for mouse PMN in a dose-dependent fashion when tested in vitro in the absence of serum. Culture supernatants of S. aureus exhibited weak chemotactic activity in vitro and did not induce PMN recruitment in the lungs when aerosolized to DBA/2J mice. The results suggest that chemotactins released by P. aeruginosa may be an important virulence factor and play a significant role in lung tissue damage.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-1103633, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-1167871, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-12369, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-13278318, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-14908062, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-165239, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-342601, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-3920067, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-4384494, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-492335, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-5776515, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6086529, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-619716, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6259695, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6301011, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6301768, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6340415, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6340986, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6351681, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6361563, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6404822, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6406026, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6427360, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6433761, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6584527, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6732053, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6740645, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6807846, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6815088, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6989919, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-6994210, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-7000913, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-7052569, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-7081809, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-7370105, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-7382721, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-779549, http://linkedlifedata.com/resource/pubmed/commentcorrection/3926643-96277
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of chemotactins released by Staphylococcus aureus and Pseudomonas aeruginosa on the murine respiratory tract.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't