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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1985-9-23
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pubmed:abstractText |
C57BL/6 mice generate influenza-specific cytotoxic T cells (Tc) which are predominantly restricted to Db. The induction of a Kb-restricted response in H-2b mice has been controversial. We show here that the magnitude of Kb-restricted anti-influenza Tc responses is affected by the type of stimulator cell. Both in vivo and in vitro, secondary responses in the spleen show strong selection for Db-restricted Tc. However, limiting dilution analyses show that intranasal (i.n.) influenza infection primes Kb- as well as Db-restricted Tc in C57BL mice at a ratio of 1:2--but different cell types acting as stimulator cells vary in their ability to induce secondary Kb-restricted influenza-specific Tc (B lymphoblasts greater than macrophages greater than spleen cells greater than T lymphoblasts). Thus, the site of infection and antigen presentation can determine the MHC restriction of T-cell responses.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-100569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-194164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-212503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-300483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6174627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6191873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6193967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6198430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6220111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6454725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6572399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-67564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6799839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6806380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-6968871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-7461728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-77879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3926637-92183
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
601-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3926637-Animals,
pubmed-meshheading:3926637-Antigen-Presenting Cells,
pubmed-meshheading:3926637-Antigens, Viral,
pubmed-meshheading:3926637-Cytotoxicity, Immunologic,
pubmed-meshheading:3926637-Female,
pubmed-meshheading:3926637-Genes, MHC Class II,
pubmed-meshheading:3926637-Immunization,
pubmed-meshheading:3926637-Immunologic Memory,
pubmed-meshheading:3926637-Influenza A virus,
pubmed-meshheading:3926637-Mice,
pubmed-meshheading:3926637-Mice, Inbred C57BL,
pubmed-meshheading:3926637-Orthomyxoviridae Infections,
pubmed-meshheading:3926637-Spleen,
pubmed-meshheading:3926637-T-Lymphocytes, Cytotoxic
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pubmed:year |
1985
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pubmed:articleTitle |
Induction of Kb-restricted anti-influenza cytotoxic T cells in C57BL mice: importance of stimulator cell type and immunization route.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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