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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1985-9-3
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pubmed:abstractText |
We have cloned 26 different class I genes that are located in the major histocompatibility complex of the C57BL/10 mouse. Two of the three class I genes found in the H-2 complex encode the H-2Kb and H-2Db antigens; the other 23 class I genes map to the adjacent Tla complex. We have grouped the cosmids containing these genes into three clusters: one cluster links the H-2K and I-A regions, one cluster links the H-2D and Qa-2 regions, and the final cluster maps to the TL region. The class I gene organizations in the Qa-2 and TL regions of the C57BL/10 and BALB/c mice are generally similar, but there are several polymorphic segments. The Qa-2 region of both mice seems to have evolved by the duplication of gene pairs; furthermore, the H-2K region may have been generated by the translocation of a gene pair from the Qa-2 region. We have evidence that several of the genes in the Qa-2 region are expressed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-9446
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2736-40
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:3926542-Animals,
pubmed-meshheading:3926542-Antigens, Surface,
pubmed-meshheading:3926542-Chromosome Mapping,
pubmed-meshheading:3926542-Cloning, Molecular,
pubmed-meshheading:3926542-Genes,
pubmed-meshheading:3926542-Genes, MHC Class II,
pubmed-meshheading:3926542-H-2 Antigens,
pubmed-meshheading:3926542-Histocompatibility Antigens,
pubmed-meshheading:3926542-Histocompatibility Antigens Class I,
pubmed-meshheading:3926542-Mice,
pubmed-meshheading:3926542-Mice, Inbred BALB C,
pubmed-meshheading:3926542-Mice, Inbred C57BL
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pubmed:year |
1985
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pubmed:articleTitle |
Evolution and expression of the transplantation antigen gene family.
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pubmed:publicationType |
Journal Article
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