| pubmed-article:3926323 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3926323 | lifeskim:mentions | umls-concept:C0003069 | lld:lifeskim |
| pubmed-article:3926323 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3926323 | lifeskim:mentions | umls-concept:C1415993 | lld:lifeskim |
| pubmed-article:3926323 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:3926323 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:3926323 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:3926323 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3926323 | pubmed:dateCreated | 1985-9-4 | lld:pubmed |
| pubmed-article:3926323 | pubmed:abstractText | Transgenic mice containing a microinjected rearranged immunoglobulin (Ig) mu heavy chain gene were examined for the effects on DNA rearrangement of the endogenous Ig genes. Abelson murine leukemia virus (A-MuLV) cell lines were isolated from pre-B cells of transgenic mice and of normal littermates. Microinjected mu gene RNA and a mu heavy chain protein were synthesized in every transgenic A-MuLV cell line. Only 10% of normal mouse A-MuLV transformants synthesized mu protein. A germ-line JH allele was observed in 40% of the transgenic lines, demonstrating that the block to endogenous Ig DNA rearrangement occurred at the first step of heavy chain DNA joining. All alleles were rearranged in normal mouse A-MuLV lines. Germline JH alleles were also detected in 10% of the transgenic hybridomas derived from proliferating B cells. Our results support a model of active prevention of rearrangement by the product of successfully rearranged mu genes. | lld:pubmed |
| pubmed-article:3926323 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3926323 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3926323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3926323 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3926323 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3926323 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:3926323 | pubmed:author | pubmed-author:BaltimoreDD | lld:pubmed |
| pubmed-article:3926323 | pubmed:author | pubmed-author:Imanishi-Kari... | lld:pubmed |
| pubmed-article:3926323 | pubmed:author | pubmed-author:WeaverDD | lld:pubmed |
| pubmed-article:3926323 | pubmed:author | pubmed-author:CostantiniFF | lld:pubmed |
| pubmed-article:3926323 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3926323 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:3926323 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3926323 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3926323 | pubmed:pagination | 117-27 | lld:pubmed |
| pubmed-article:3926323 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:meshHeading | pubmed-meshheading:3926323-... | lld:pubmed |
| pubmed-article:3926323 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3926323 | pubmed:articleTitle | A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. | lld:pubmed |
| pubmed-article:3926323 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3926323 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3926323 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3926323 | lld:pubmed |
