Linked Life Data

3925407

Source:http://linkedlifedata.com/resource/pubmed/id/3925407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-8-21
pubmed:abstractText
Oral administration of 0.001% 4NQO in drinking water resulted in a high incidence of tongue carcinoma in rats. In other major organs, tumor induction was rarely observed. The most frequent site of tongue carcinoma was the dorsum. No metastases were found. Changes observed included carcinoma in situ and invasive carcinoma. Carcinoma in situ showed erosion, leukoplakia, and a gross papillary appearance. Histologically, most carcinomas in situ showed full-thickness alteration of epithelium. Some carcinomas in situ in papillary lesions showed slightly less than full-thickness alteration of epithelium, exhibiting downward, well-differentiated growth. Invasive carcinomas were either endophytic or exophytic. Histologic grading of invasive carcinoma varied from highly to poorly differentiated. The method described offers a new experimental animal model of tongue carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0030-4220
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
600-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't