| pubmed-article:3925348 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:3925348 | lifeskim:mentions | umls-concept:C2697616 | lld:lifeskim |
| pubmed-article:3925348 | pubmed:issue | 6021 | lld:pubmed |
| pubmed-article:3925348 | pubmed:dateCreated | 1985-8-19 | lld:pubmed |
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| pubmed-article:3925348 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3925348 | pubmed:abstractText | Interferons are a family of proteins first identified by their ability to induce cellular resistance to infection by many viruses. In addition to the antiviral properties it shares with the alpha- and beta-interferons, gamma-interferon (IFN-gamma), a lymphokine secreted by activated T cells, activates macrophages, stimulates B cells, increases fibroblast and endothelial cell resistance to many nonviral intracellular parasites and modulates cell-surface proteins central to immune cell regulation. To identify molecules involved in the IFN-gamma response and characterize their modulation, we have isolated genes that are induced following recombinant IFN-gamma treatment of U937 cells, a histiocytic lymphoma cell line with monocytic characteristics. We report here the molecular cloning and characterization of a gene regulated by rIFN-gamma in U937 cells as well as in human mononuclear cells, fibroblasts and endothelial cells. Messenger RNA from this gene is induced within 30 min of rIFN-gamma treatment and demonstrates maximal (greater than 30-fold) accumulation within 5 h. Increased transcription is partly responsible for this accumulation. This gene encodes a protein of relative molecular mass (Mr) 12,378 which has significant amino-acid homology to platelet factor-4 and beta-thromboglobulin, two chemotatic proteins released by platelets on degranulation. This IFN-gamma-inducible protein may be a member of a family of proteins involved in the inflammatory process. | lld:pubmed |
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| pubmed-article:3925348 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3925348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3925348 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3925348 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3925348 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3925348 | pubmed:author | pubmed-author:UnkelessJ CJC | lld:pubmed |
| pubmed-article:3925348 | pubmed:author | pubmed-author:RavetchJ VJV | lld:pubmed |
| pubmed-article:3925348 | pubmed:author | pubmed-author:LusterA DAD | lld:pubmed |
| pubmed-article:3925348 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3925348 | pubmed:volume | 315 | lld:pubmed |
| pubmed-article:3925348 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3925348 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3925348 | pubmed:pagination | 672-6 | lld:pubmed |
| pubmed-article:3925348 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3925348 | pubmed:meshHeading | pubmed-meshheading:3925348-... | lld:pubmed |
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| pubmed-article:3925348 | pubmed:meshHeading | pubmed-meshheading:3925348-... | lld:pubmed |
| pubmed-article:3925348 | pubmed:articleTitle | Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. | lld:pubmed |
| pubmed-article:3925348 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3925348 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3925348 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3925348 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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